| Registro completo |
| Provedor de dados: |
International Journal of Morphology
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| País: |
Chile
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| Título: |
Death-Associated Protein Kinase is Underexpressed in High-Grade Oral Squamous Cell Carcinoma
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| Autores: |
Meneses,Ismário Silva de
Souza,Rafael Reis de
Jeraldo,Verónica de Lourdes Sierpe
Cavalcante,Danielle Rodrigues Ribeiro
Reis,Francisco Prado
Albuquerque Júnior,Ricardo Luiz Cavalcanti de
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| Data: |
2010-06-01
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| Ano: |
2010
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| Palavras-chave: |
Immunohistochemistry
DAP kinase
Apoptosis
Squamous cell carcinoma
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| Resumo: |
An immunohistochemical analysis of 40 cases of oral squamous cell carcinoma was performed to evaluate the relationship between the expression pattern of death-associated protein kinase (DAPk) positive cells with the histological malignancy grading of these lesions. According to our results, eleven cases (27.5%) were high-grade malignancy tumours and 29 (72.5%) were low-grade ones. We found that 92.86% of the low-grade tumours were positive to anti-DAP kinase antibody whereas only 7.14% of the high-grade tumours presented positivity, and this difference was statistically significant (p<0.01). Sixteen (55.2%) of the low-grade carcinomas exhibited moderate immunoreactivity whereas ten cases (34.5%) showed weak staining and three cases (10.3%) were negative tumours. Immunostaining was lacking in nine (81.8%) of the high-grade carcinomas and "weak" in the two (18.2%) remaining cases. Thus, DAPk expression is significantly decreased in high-grade oral carcinomas, and evidences indicate that it might be related to the severity of cytological atypia.
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| Tipo: |
Journal article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200044
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| Editor: |
Sociedad Chilena de Anatomía
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| Formato: |
text/html
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| Fonte: |
International Journal of Morphology v.28 n.2 2010
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